![]() ![]() This shutdown may increase an organisms susceptibility to secondary infections.Ĭopyright 2015, American Association for the Advancement of Science. This disrupted organization reduces the capacity of SCS macrophages to retain and present antigen in a subsequent secondary infection, resulting in diminished B cell responses. However, how infection affects SCS macrophages remains largely unexplored. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection Article Full-text available Feb 2015 SCIENCE Mauro Gaya Angelo Castello Beatriz Montaner Facundo Batista The layer of macrophages at the subcapsular sinus (SCS) captures pathogens entering the lymph node, preventing their global dissemination and triggering an immune response. Request full-text PDF Citations (0) References (2) ResearchGate has not been able to resolve any citations for this publication. ![]() Bhv 1 Codec For Free No Fullĭiscover the worlds research 20 million members 135 million publications 700k research projects Join for free No full-text available To read the full-text of this research, you can request a copy directly from the author. There, specialized cells called subcapsular sinus (SCS) macrophages capture these antigens and use them to initiate humoral immunity.ĭisrupting SCS macrophages had important consequences: Bacterially infected mice could not respond as efficiently to a subsequent viral infection. References (2) Abstract During infections, lymph nodes are command central.įragments from invading pathogens enter lymph nodes through the lymph. Request full-text Download citation Copy link Link copied Request full-text Download citation Copy link Link copied To read the full-text of this research, you can request a copy directly from the author. ![]()
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